camp sodium salt

Names

[ Name ]:
camp sodium salt

[Synonym ]:
4H-Furo[3,2-d]-1,3,2-dioxaphosphorin-7-ol, 6-(6-amino-9H-purin-9-yl)tetrahydro-2-hydroxy-, 2-oxide, sodium salt, (4aR,6R,7R,7aS)- (1:1)
Adenosine 3',5'-cyclic monophosphate sodium salt monohydrate
3’,5‘-Cyclic AMP sodium salt
Adenosine 3',5'-Cyclic Monophosphate Sodium Salt Hydrate
Sodium (4aR,6R,7R,7aS)-6-(6-amino-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide
3',5'-Cyclic AMP Sodium Salt Hydrate
Adenosine 3’,5‘-cyclic monophosphate sodium salt monohydrate
MFCD00069736
CAMP SODIUM SALT

Biological Activity

[Description]:

Cyclic AMP (Cyclic adenosine monophosphate) sodium, adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP sodium is an important second messenger in many biological processes[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[Target]

Human Endogenous Metabolite

Microbial Metabolite

[In Vitro]

Cyclic AMP (Cyclic adenosine monophosphate) sodium modulates mediator generation. Cyclic AMP sodium suppresses the expression of pro-inflammatory cytokines, including TNF-α and IL-12, and enhances the production of the anti-inflammatory cytokine IL-10.

[References]

[1]. G M Fimia, et al. Cyclic AMP signaling. J Cell Sci. 2001 Jun;114(Pt 11):1971-2.

[2]. Paolo Sassone-Corsi, et al. The cyclic AMP pathway. Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12):a011148.

[3]. Aronoff DM, et, al. Short communication: differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis. J Interferon Cytokine Res. 2006 Nov;26(11):827-33.

Chemical & Physical Properties

[ Boiling Point ]:
701.5ºC at 760 mmHg

[ Melting Point ]:
219 - 220ºC

[ Molecular Formula ]:
C₁₀H₁₁N₅NaO₆P

[ Molecular Weight ]:
351.19

[ Flash Point ]:
378ºC

[ Exact Mass ]:
351.034454

[ PSA ]:
167.48000

[ LogP ]:
0.20200

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 50 mg/mL | Soluble in water (50 mg/ml).

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7357900

CHEMICAL NAME :: Adenosine, cyclic 3',5'-(hydrogen phosphate)-, monosodium salt

CAS REGISTRY NUMBER :: 37839-81-9

LAST UPDATED :: 199409

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H11-N5-O6-P.Na

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14300 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 1(2),15,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 395 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - ataxia

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 1(2),15,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 645 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - ataxia

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 1(2),15,1976

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
AU7357900

[ HS Code ]:
29349990

Precursor & DownStream

Precursor

DownStream

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Related Compounds

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