PHOSMET-OXON

Names

[ Name ]:
PHOSMET-OXON

[Synonym ]:
Oxoimidan
ENT 25,707
R 1571
Thiophosphorsaeure-O,O'-dimethylester-S-phthalimidomethylester
Imidoxon
R 1571A
Stauffer R-1571
thiophosphoric acid O,O'-dimethyl ester-S-phthalimidomethyl ester
Phosmet oxon
Stauffer R-1571-A

Biological Activity

[Description]:

Phosmet oxon (Imidoxon) is a main and toxic metabolite of phosmet. Phosmet is a cholinesterase inhibitor insecticide used on pome and stone fruits[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Lucini L, et al. Performance and matrix effect observed in QuEChERS extraction and tandem mass spectrometry analyses of pesticide residues in different target crops. J Chromatogr Sci. 2011 Oct;49(9):709-14.

Chemical & Physical Properties

[ Density]:
1.451g/cm3

[ Boiling Point ]:
405.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₂NO₅PS

[ Molecular Weight ]:
301.26

[ Flash Point ]:
199.1ºC

[ Exact Mass ]:
301.01700

[ PSA ]:
108.02000

[ LogP ]:
2.31210

[ Index of Refraction ]:
1.589

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TF6500000

CHEMICAL NAME :: Phosphorothioic acid, S-((1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl) O,O-dimethyl ester

CAS REGISTRY NUMBER :: 3735-33-9

BEILSTEIN REFERENCE NO. :: 0264370

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H12-N-O5-P-S

MOLECULAR WEIGHT :: 301.27

WISWESSER LINE NOTATION :: T56 BVNVJ C1SPO&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705) Volume(issue)/page/year: 20,23,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 46 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,147,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 122 mg/kg/1W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,147,1964

Safety Information

[ Hazard Codes ]:
F: Flammable;Xn: Harmful;

[ Risk Phrases ]:
11-38-48/20-63-65-67

[ Safety Phrases ]:
S46;S62;S36/S37

[ RIDADR ]:
UN 2783

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%