Flavokawain C

Names

[ Name ]:
Flavokawain C

[Synonym ]:
4',6'-dimethoxy-2',4-dihydroxychalcone
Flavokavain C
1-(2-hydroxy-4,6-dimethoxy)phenyl-3-(4-hydroxy)phenyl-2-propen-1-one
2',4-Dihydroxy-4',6'-dimethoxychalcone
2'-hydroxy-4,6'-dimethoxychalcone
2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-
(E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
2299311
(2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
Flavokawain C
Flavokawin C
flavokawin
(2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
QR D1U1VR BQ DO1 FO1 &&E Form
4',6'-di-O-methylchalconaringenin

Biological Activity

[Description]:

Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC50 of 12.75 μM for HCT 116 cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Phang CW, et al. Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. PLoS One. 2016 Feb 9;11(2):e0148775.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
556.0±50.0 °C at 760 mmHg

[ Melting Point ]:
179-182℃

[ Molecular Formula ]:
C₁₇H₁₆O₅

[ Molecular Weight ]:
300.306

[ Flash Point ]:
207.3±23.6 °C

[ Exact Mass ]:
300.099762

[ PSA ]:
75.99000

[ LogP ]:
3.48

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.637

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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