4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide

Names

[ Name ]:
4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide

[Synonym ]:
4-Methyl-2-oxo-2H-chromen-7-yl 2-acetamido-2-deoxy-β-D-glucopyranoside
4-Methylumbelliferyl 2-Acetamido-2-deoxy-β-D-glucopyranoside
GLCNAC1-B-4MU
MFCD00065481
4-Methylumbelliferyl-N-acetyl-ß-D-glucosaminide
4-Methylumbelliferyl-N-acetyl-β-D-glucosaminide
7-((2-Acetamido-2-deoxy-β-D-glucopyranosyl)oxy)-4-methyl-2H-1-benzopyran-2-one
EINECS 253-333-0
Methylumbelliferyl-N-acetyl-b-D-glucosaminide
2H-1-Benzopyran-2-one, 7-[[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]oxy]-4-methyl-
T66 BOVJ E1 IO- BT6OTJ CMV1 DQ EQ F1Q &&β-D-Gluco Form

Biological Activity

[Description]:

4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside is a fluorogenic substrate for N-acetyl-β-D-glucosaminidase[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

The enzyme functionality is assessed by its ability remove terminal β-glycosidically bound N-acetylglucosamine and N-acetylgalactosamine residues from 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside[1].

[References]

[1]. Li J, et, al. Identification of a specific inhibitor of nOGA - a caspase-3 cleaved O-GlcNAcase variant during apoptosis. Biochemistry (Mosc). 2012 Feb;77(2):194-200.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
732.2±60.0 °C at 760 mmHg

[ Melting Point ]:
208-210 °C

[ Molecular Formula ]:
C₁₈H₂₁NO₈

[ Molecular Weight ]:
379.361

[ Flash Point ]:
396.6±32.9 °C

[ Exact Mass ]:
379.126709

[ PSA ]:
138.46000

[ LogP ]:
0.34

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.632

[ Storage condition ]:
−20°C

[ Stability ]:
Light Sensitive - Protect from Light

[ Water Solubility ]:
DMF: 20 mg/mL, clear, colorless

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Tay-Sachs disease heterozygote detection: use of a centrifugal analyser for automation of hexosaminidase assays with two different artificial substrates.

J. Med. Genet. 28(2) , 101-9, (1991)

An assay for measuring hexosaminidase A in serum and leucocytes is described in which a centrifugal analyser is used for automation of the enzyme assays after manual heat inactivation. The assay was u...

TNFalpha-induced macrophage death via caspase-dependent and independent pathways.

Apoptosis 14(3) , 320-32, (2009)

Macrophages are the principal source of TNFalpha, yet they are highly resistant to TNFalpha-mediated cell death. Previously, employing in vitro differentiated human macrophages, we showed that followi...

A rapid method for detection of N-acetylglucosaminidase-type chitinase activity in crossed immunoelectrophoresis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis gels using 4-methylumbelliferyl-N-acetyl-D-glucosaminide as substrate.

Electrophoresis 15(5) , 662-5, (1994)

A method for the detection of N-acetylglucosaminidase (GlcNAcase) activity has been developed by using 4-methyl-umbelliferyl-N-acetyl-D-glucosaminide (4-MU-GlcNAc) as substrate in crossed immunoelectr...

Related Compounds

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