MST312

Names

[ Name ]:
MST312

[Synonym ]:
telomerase inhibitor IX
IN1063
N,N'-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]
N,N'-bis(2,3-dihydroxybenzoyl)-1,3-phenylenediamine
N,N-1,3-phenylenebis-(2,3-dihydroxybenzamide)
MST-312
1,3-bis(2,3-dihydroxybenzamido)benzene
Benzamide,N,N'-1,3-phenylenebis[2,3-dihydroxy
MST312

Biological Activity

[Description]:

MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Telomerase

[Target]

telomeras[1]

[In Vitro]

MST-312 (2~8 μM; 0~72 hours; U-266 cells) reduces cellular viability in a dose dependent and time-dependent manner[1]. MST-312 (2~8 μM; 48 hours; U-266 cells) induces cell apoptosis in a dose-dependent manner[1]. MST-312 (2 μM; 48 hours; U-266 cells) up-regulates the pro-apoptotic gene Bax and down-regulates the anti-apoptotic gene Bcl-2 and suppresses the expression of c-Myc and hTERT genes[1]. Cell Viability Assay[1] Cell Line: U-266 cells Concentration: 2~8 μM Incubation Time: 0~72 hours Result: The viability of U-266 cells was substantially decreased in a dose dependent and time-dependent manner, in response to exposure to MST-312. Apoptosis Analysis[1] Cell Line: U-266 cells Concentration: 2~8 μM Incubation Time: 48 hours Result: Induced cell apoptosis in a dose-dependent manner. RT-PCR[1] Cell Line: U-266 cells Concentration: 2 μM Incubation Time: 48 hours Result: Up-regulated the pro-apoptotic gene Bax and down-regulated the anti-apoptotic gene Bcl-2 and suppressed the expression of c-Myc and hTERT genes.

[References]

[1]. Ameri Z, et al. Telomerase inhibitor MST-312 induces apoptosis of multiple myeloma cells and down-regulation of anti-apoptotic, proliferative and inflammatory genes. Life Sci. 2019;228:66-71.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₆N₂O₆

[ Molecular Weight ]:
380.35100

[ Exact Mass ]:
380.10100

[ PSA ]:
146.10000

[ LogP ]:
3.78160

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H400

[ Precautionary Statements ]:
P273

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

MST-312 Alters Telomere Dynamics, Gene Expression Profiles and Growth in Human Breast Cancer Cells.

J. Nutrigenet. Nutrigenomics 7 , 283-98, (2015)

Targeting telomerase is a potential cancer management strategy given that it allows unlimited cellular replication in the majority of cancers. Dysfunctional telomeres are recognized as double-strand b...

Fluorescence-based duplex-quadruplex competition test to screen for telomerase RNA quadruplex ligands.

Nucleic Acids Res. 39 , e21, (2011)

RNA and DNA guanine-rich sequences can adopt unusual structures called Guanine quadruplexes (G4). A quadruplex-prone RNA sequence is present at the 5'-end of the 451-nt-long RNA component of telomeras...

Related Compounds

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