API-1

Names

[ Name ]:
API-1

[Synonym ]:
NSC 177223

Biological Activity

[Description]:

API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC50 of ∼0.8 μM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces apoptosis by synergizing with TNF-related apoptosis-inducing ligand (TRAIL)[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[References]

[1]. Donghwa Kim, et al. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J Biol Chem. 2016 Oct 21;291(43):22856.

[2]. Donghwa Kim, et al. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J Biol Chem. 2016 Oct 21;291(43):22856.

Chemical & Physical Properties

[ Density]:
1.792g/cm3

[ Boiling Point ]:
795.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₅N₅O₆

[ Molecular Weight ]:
337.28800

[ Flash Point ]:
435.1ºC

[ Exact Mass ]:
337.10200

[ PSA ]:
186.81000

[ Index of Refraction ]:
1.764

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310 + P330

[ RIDADR ]:
UN 2811 6.1 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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