8-NH2-ATP

Names

[ Name ]:
8-NH2-ATP

[Synonym ]:
8-Amino-ATP
Amino-8-ATP
8-AMINOADENOSINE-5'-O-TRIPHOSPHATE

Biological Activity

[Description]:

8-NH2-ATP, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado is reported to be potent as shown by induction of apoptosis-related cleavage of poly (ADP-ribose) polymerase[1][2].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Research Areas >> Metabolic Disease

[In Vitro]

The extensive cellular accumulation of 8-NH2-ATP has an inhibitory effect on both RNA and DNA synthesis in both glucocorticoid-sensitive and glucocorticoid-resistant myeloma cell lines[1][2].

[References]

[1]. Nancy L Krett, et al. 8-amino-adenosine is a potential therapeutic agent for multiple myeloma. Mol Cancer Ther. 2004 Nov;3(11):1411-20.

[2]. Yuji Matsuzaki, et al. ATP-association to intrabacterial nanotransportation system in Vibrio cholera. Med Mol Morphol. 2015 Dec;48(4):225-34.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₇N₆O₁₃P₃

[ Molecular Weight ]:
522.19600

[ Exact Mass ]:
522.00700

[ PSA ]:
334.58000

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.