AG-09/1

Names

[ Name ]:
AG-09/1

[Synonym ]:
2-[(6-methoxy-1H-benzimidazol-2-yl)thio]-N-(4-nitrophenyl)-acetamide

Biological Activity

[Description]:

AG-09/1 is a specific formyl peptide receptor 1 (FPR1) agonist. N-formyl peptide receptors (FPR) are important in host defense[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

FPR1[1]

[In Vitro]

N-formyl peptides activate phagocytes through G protein-coupled receptors known as FPR. FPR1 was the first FPR cloned and encodes a high-affinity receptor for fMLF[1].

[References]

[1]. Andrei I Khlebnikov, et al. Computational Structure-Activity Relationship Analysis of Small-Molecule Agonists for Human Formyl Peptide Receptors. Eur J Med Chem. 2010 Nov;45(11):5406-19.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₄N₄O₄S

[ Molecular Weight ]:
358.37200

[ Exact Mass ]:
358.07400

[ PSA ]:
138.13000

[ LogP ]:
3.80670

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport