Diethylaminoethyl

Names

[ Name ]:
Diethylaminoethyl

[Synonym ]:
Aprofenum [INN-Latin]
Aprophenum
2,2-Diphenyl-propionsaeure-(2-diaethylamino-aethylester)
Propionic acid,2,2-diphenyl-,2-(diethylamino)ethyl ester
Aprofeno [INN-Spanish]
Diphenyl-methyl-essigsaeure-(2-aethyl-diaethylamin)-ester
2-Diethylaminoethyl 2,2-diphenylpropionate
Aprofene
Aprofen
2,2-diphenyl-propionic acid-(2-diethylamino-ethyl ester)
Aprophen

Biological Activity

[Description]:

Aprophen (Aprofene) is an antimuscarinic inhibitor. Aprophen can be used for the research of central nervous system[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[References]

[1]. A comparison of the antimuscarinic properties of aprophen with those of some other anticholinergic drugs. Issue: MRL-R-794. Pages: 10 pp. Report 1980.

Chemical & Physical Properties

[ Density]:
1.041g/cm3

[ Boiling Point ]:
434.8ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₂₇NO₂

[ Molecular Weight ]:
325.44500

[ Flash Point ]:
132.5ºC

[ Exact Mass ]:
325.20400

[ PSA ]:
29.54000

[ LogP ]:
3.87760

[ Index of Refraction ]:
1.537

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UF2032500

CHEMICAL NAME :: Propionic acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester

CAS REGISTRY NUMBER :: 3563-01-7

BEILSTEIN REFERENCE NO. :: 2509326

LAST UPDATED :: 199707

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H27-N-O2

MOLECULAR WEIGHT :: 325.49

WISWESSER LINE NOTATION :: 2N2&2OVX1&R&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 4,7,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 31,53,1968

Safety Information

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%