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FTI-2153

Names

[ CAS No. ]:
344900-92-1

[ Name ]:
FTI-2153

Biological Activity

[Description]:

FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC50 of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. Anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Sun J, et al. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res. 1999 Oct 1;59(19):4919-26.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H30N4O3S

[ Molecular Weight ]:
466.59600

[ Exact Mass ]:
466.20400

[ PSA ]:
121.41000

[ LogP ]:
4.48120

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds