atorvastatin calcium trihydrate
Names
[ CAS No. ]:
344423-98-9
[ Name ]:
atorvastatin calcium trihydrate
[Synonym ]:
atorvastatin calcium trihydrate
1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt, (βR,δR)-, hydrate (2:1:3)
Torvast
Atorvastatin Calcium Salt Trihydrate
Atorvastatin hemicalcium salt sesquihydrate
Lipitor
1H-Pyrrole-1-heptanoicacid, 2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-,calcium salt, hydrate (2:1:3), (bR,dR)-
Calcium (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate hydrate (1:2:3)
Sortis
Totalip
Chemical & Physical Properties
[ Molecular Formula ]:
C66H74CaF2N4O13
[ Molecular Weight ]:
1209.388
[ Exact Mass ]:
1208.484619
[ PSA ]:
256.93000
[ LogP ]:
9.91090
[ Water Solubility ]:
Very slightly soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H319-H360D
[ Precautionary Statements ]:
P201-P280-P305 + P351 + P338-P308 + P313-P337 + P313
[ Hazard Codes ]:
T
[ Risk Phrases ]:
61-36
[ Safety Phrases ]:
53-26-45
[ RIDADR ]:
NONH for all modes of transport
Articles
J. Med. Virol. 87(1) , 141-53, (2014)
Vasculoprotective and cholesterol-lowering properties are hallmarks of statins. Recently, statins have been found to exhibit antiviral activity. Little is known about the potential of statins against ...
Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug-drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys.Drug Metab. Pharmacokinet. 30(2) , 198-204, (2015)
Since drug-drug interaction (DDI) can affect organic anion-transporting polypeptide (OATP) and cause clinical events, prediction of such DDI is important in early clinical development. Although statin...
Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin.Biol. Chem. 396(1) , 71-80, (2014)
Macrophages express several lysosomal cysteine proteases such as cathepsins and legumain. In this study, we assessed the expression, activity and secretion of legumain in cellular models of monocytes/...