(+)-Biotin-ONP

Names

[ Name ]:
(+)-Biotin-ONP

[Synonym ]:
1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, 4-nitrophenyl ester, (3aS,4S,6aR)-
Biotin-p-nitrophenyl ester
D-biotin 4-nitrophenyl ester
MFCD00005540
D-Biotin P-Nitrophenyl Ester
(+)-Biotin 4-nitrophenyl ester
Biotinyl-4-nitrophenyl ester
D-(+)-biotin 2-nitrophenyl ester
4-Nitrophenyl 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate
BNP,D-Biotin 4-nitrophenyl ester
4-Nitrophenyl (+)-biotinate

Biological Activity

[Description]:

(+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
642.9±50.0 °C at 760 mmHg

[ Melting Point ]:
163-165ºC

[ Molecular Formula ]:
C₁₆H₁₉N₃O₅S

[ Molecular Weight ]:
365.404

[ Flash Point ]:
342.6±30.1 °C

[ Exact Mass ]:
365.104553

[ PSA ]:
138.55000

[ LogP ]:
1.89

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.584

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S22-S24/25