Dihydrouracil-d4

Names

[ CAS No. ]:
334473-41-5

[ Name ]:
Dihydrouracil-d4

Biological Activity

[Description]:

Dihydrouracil-d4 is the deuterium labeled Dihydrouracil[1]. Dihydrouracil (HY-W012926), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[2][3].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化，可能影响药物的药代动力学和代谢特征，受到广泛关注[1]。

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Henricks LM, et, al. Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers. Br J Clin Pharmacol. 2018 Dec;84(12):2761-2769.  

[3]. Jacobs BAW, et, al. The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases. Eur J Clin Pharmacol. 2018 Jun;74(6):737-744.  

Chemical & Physical Properties

[ Molecular Formula ]:
C4H2D4N2O2

[ Molecular Weight ]:
118.12700

[ Exact Mass ]:
118.06800

[ PSA ]:
58.20000

Precursor & DownStream

Precursor

DownStream

Related Compounds