ML-SA1

Names

[ Name ]:
ML-SA1

[Synonym ]:
ML-SA1

Biological Activity

[Description]:

ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Infection

[Target]

IC50: 8.3 μM (DENV2)[1]. IC50: 52.99 μM (ZIKV)[1]

[In Vitro]

ML-SA1 (25 μM; 0~14 hours; A549 cells) possibly affects the entry of DENV2 into host cells[1]. ML-SA1 (0~200 μM; A549 cells) shows that there is no cytotoxicity to the cell line observed, even at concentrations up to 200 μM. ML-SA1 (0~50 μM; A549 cells) significantly suppresses DENV2 at the RNA levels and the IC50 is 8.93 μM[1].ML-SA1 results in a dose-dependent decrease in ZIKV in A549 cells at both the RNA and protein levels, and the IC50 value of ML-SA1 against ZIKV RNA is 52.99 μM. ML-SA1, as an activator of TRPMLs, appears to be a potent inhibitor of DENV2 and ZIKV in vitro. ML-SA1 promotes lysosomal acidification and protease activity to inhibit viral infection. ML-SA1 can induce autophagy in Huh7 cells or A549 cells[1]. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 25 μM Incubation Time: 0~14 hours Result: Possibly affected the entry of DENV2 into host cells.

[References]

[1]. Xia Z, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020;182:104922.

Chemical & Physical Properties

[ Density]:
1.226±0.06 g/cm3

[ Boiling Point ]:
546.7±43.0 °C

[ Molecular Formula ]:
C₂₂H₂₂N₂O₃

[ Molecular Weight ]:
362.42200

[ Exact Mass ]:
362.16300

[ PSA ]:
57.69000

[ LogP ]:
3.60450

[ Appearance of Characters ]:
white to beige

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble5mg/mL, clear (warmed)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H410

[ Precautionary Statements ]:
P273-P301 + P310-P501

[ Hazard Codes ]:
T

[ Risk Phrases ]:
25-50/53

[ Safety Phrases ]:
60-61

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ WGK Germany ]:
3

[ HS Code ]:
2933499090

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%