5-Iodo-indirubin-3'-monoxime

Names

[ CAS No. ]:
331467-03-9

[ Name ]:
5-Iodo-indirubin-3'-monoxime

Biological Activity

[Description]:

5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

GSK-3β:9 nM (IC50)

Cdk5/p25:20 nM (IC50)

Cdk1/cyclin B:25 nM (IC50)


[References]

[1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H10IN3O2

[ Molecular Weight ]:
403.17

Related Compounds