Phortress

Names

[ Name ]:
Phortress

[Synonym ]:
MFCD06407804
AXR52N9SMF
N-[4-(5-Fluoro-1,3-benzothiazol-2-yl)-2-methylphenyl]-L-lysinamide dihydrochloride
Hexanamide, 2,6-diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]-, (2S)-, hydrochloride (1:2)

Biological Activity

[Description]:

Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

[References]

[1]. Bradshaw TD, et al. In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. Br J Cancer. 2002 Apr 22;86(8):1348-54.

[2]. Bradshaw TD, Westwell AD. The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate. Curr Med Chem. 2004 Apr;11(8):1009-21.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₅Cl₂FN₄OS

[ Molecular Weight ]:
459.408

[ Exact Mass ]:
458.111023

Related Compounds

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