chlorogentisyl alcohol

Names

[ Name ]:
chlorogentisyl alcohol

[Synonym ]:
3-Chlorgentisylalkohol
3-Chlorogentisyl alcohol
2,5-Dihydroxy-3-chlorobenzyl alcohol
2-(Hydroxymethyl)-6-chlorohydroquinone
6-Chlorogentisylalcohol
2-Chloro-6-(hydroxymethyl)-1,4-benzenediol
2-chloro-6-(hydroxymethyl)benzene-1,4-diol
3-chloro-2,5-dihydroxy benzyl alcohol
AMUDOL

Biological Activity

[Description]:

3-Chlorogentisyl alcohol is a potent E. coli β-glucuronidase inhibitor with an IC50 value of 0.74 µM, an Ki value of 0.58 µM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 0.74 µM (β-glucuronidase)[1]

[In Vitro]

3-Chlorogentisyl alcohol (compound 1) (20 µM; 24 h) shows antiproliferative activity in Namalwa, U266 cells[1]. Cell Proliferation Assay[1] Cell Line: Namalwa, U266 cells Concentration: 20 µM Incubation Time: 24 h Result: Showed antiproliferative activity with the viability rate of 70.40% and 94.08% in Namalwa, U266 cells, respectively.

[References]

[1]. YichaoGe， et al. Exploring gabosine and chlorogentisyl alcohol derivatives from a marine-derived fungus as EcGUS inhibitors with informatic assisted approaches. European Journal of Medicinal Chemistry, 2022, 114699.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₇ClO₃

[ Molecular Weight ]:
174.58200

[ Exact Mass ]:
174.00800

[ PSA ]:
60.69000

[ LogP ]:
1.32750

chlorogentisyl alcohol

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds