Dapsone hydroxylamine

Names

[ Name ]:
Dapsone hydroxylamine

[Synonym ]:
N-[4-(4-aminophenyl)sulfonylphenyl]hydroxylamine

Biological Activity

[Description]:

Dapsone hydroxylamine (DDS-NOH) induces methemoglobinemia. Dapsone hydroxylamine inhibits catalase (CAT) activity and reactive oxygen species generation. Dapsone hydroxylamine also has anti-inflammatory activity[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Albuquerque RV, et al. In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells. PLoS One. 2015 Aug 18;10(8):e0134768.

[2]. Wozel G, et al. Dapsone hydroxylamine inhibits the LTB4-induced chemotaxis of polymorphonuclear leukocytes into human skin: results of a pilot study. Inflamm Res. 1997 Oct;46(10):420-2.

Chemical & Physical Properties

[ Density]:
1.464g/cm3

[ Boiling Point ]:
531.1ºC at 760mmHg

[ Melting Point ]:
194ºC dec.

[ Molecular Formula ]:
C₁₂H₁₂N₂O₃S

[ Molecular Weight ]:
264.30000

[ Flash Point ]:
275ºC

[ Exact Mass ]:
264.05700

[ PSA ]:
100.80000

[ LogP ]:
3.63770

[ Index of Refraction ]:
1.69

[ Storage condition ]:
Amber Vial, -20°C Freezer

[ Stability ]:
Light Sensitive, Temperature Sensitive

Safety Information

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%