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ICA 110381

Names

[ CAS No. ]:
325457-99-6

[ Name ]:
ICA 110381

[Synonym ]:
2-acetamido-6-chloropyridine

Biological Activity

[Description]:

ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

EC50: 0.38 μM (KCNQ2/Q3 potassium channel)[1] IC50: 15 μM (KCNQ1)[1]


[References]

[1]. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H8Cl2N2O

[ Molecular Weight ]:
267.11

[ Exact Mass ]:
266.00100

[ PSA ]:
41.99000

[ LogP ]:
3.71370

Synthetic Route

Click to get detail synthetic route

Related Compounds