Adenine hemisulfate

Names

[ CAS No. ]:
321-30-2

[ Name ]:
Adenine hemisulfate

[Synonym ]:
diadenine sulphate
Adenine Sulfate Dihydrate
6-Aminopurine hemisulfate salt
9H-Purin-6-amine sulfate (2:1)
EINECS 206-286-5
Bis(6-amino-9H-purin-1-ium) sulfate
denine,sulfate
Adenine sulfate salt
VITAMIN B SULFATE
Adenine sulfate
7H-Purin-6-amine, sulfate (2:1)
Adenine sulfate,synthetic
ADENINE HEMISULFATE
MFCD00213655
adeniniumsulfate
9H-purin-6-amine, sulfate (2:1)
adenine sulphate
1H-Purin-6-amine sulfate (2:1)
Adenine hemisulfate salt
Adenine sulfate hydrate
6-Aminopurine hemisulfate salt,Adenine sulfate salt
6-Aminopurine Sulfate Dihydrate
7H-Purin-6-amine sulfate
7H-Purin-6-amine sulfate (2:1)
Adenin,Sulfat

Biological Activity

[Description]:

Adenine hemisulfate (6-Aminopurine hemisulfate) is a purine derivative with a variety of roles in biochemistry, including cellular respiration, in the form of both the energy-rich adenosine triphosphate (ATP) and the cofactors nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD), and protein synthesis, as a chemical component of DNA and RNA[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[Target]

Human Endogenous Metabolite

[References]

[1]. Reader V. The assay of vitamin B(4). Biochem J. 1930;24(6):1827-31.

[2]. ORO J, et al. Synthesis of purines under possible primitive earth conditions. I. Adenine from hydrogen cyanide. Arch Biochem Biophys. 1961 Aug;94:217-27.

Chemical & Physical Properties

[ Boiling Point ]:
553.5ºC at 760mmHg

[ Melting Point ]:
285 °C (dec.)(lit.)

[ Molecular Formula ]:
C₅H₇N₅O₄S

[ Molecular Weight ]:
368.332

[ Exact Mass ]:
368.076355

[ PSA ]:
243.94000

[ LogP ]:
1.46060

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
0.4 g/100 mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7140000

CAS REGISTRY NUMBER :: 321-30-2

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C5-H5-N5.1/2H2-O4-S

MOLECULAR WEIGHT :: 821.71

WISWESSER LINE NOTATION :: T56 BM DN FN HNJ IZ &..H2.S-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 232,302,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 47,229,1979 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,24,1957 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83237 No. of Facilities: 59 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 588 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83237 No. of Facilities: 496 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 5574 (estimated) No. of Female Employees: 2982 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AU7140000

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

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