Bronidox

Names

[ Name ]:
Bronidox

[Synonym ]:
EINECS 250-001-7
5-bromo-5-nitro-1,3-dioxolane
5-Bromo-5-nitro-m-dioxane
5-bromo-5-nitro-1,3-dioxan
5-Bromo-5-nitro-1,3-dioxane
1,3-Dioxane, 5-bromo-5-nitro-
m-Dioxane, 5-bromo-5-nitro-
MFCD00101855
m-DIOXANE,5-BROMO-5-NITRO
1,3-Dioxane,5-bromo-5-nitro
Bronidox
5-Bromo-5-nitro-1.3-dioxane

Biological Activity

[Description]:

5-Bromo-5-nitro-1,3-dioxane, an antimicrobial compound, is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast. 5-Bromo-5-nitro-1,3-dioxane inhibits enzyme activity and subsequent inhibition of microbial growth by the oxidation of essential protein thiol[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. M Ghannoum, et al. Mode of Action of the Antimicrobial Compound 5-bromo-5-nitro-1,3-dioxane (Bronidox). Folia Microbiol (Praha). 1986;31(1):19-31.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
280.8±40.0 °C at 760 mmHg

[ Melting Point ]:
60°C

[ Molecular Formula ]:
C₄H₆BrNO₄

[ Molecular Weight ]:
211.999

[ Flash Point ]:
123.6±27.3 °C

[ Exact Mass ]:
210.948013

[ PSA ]:
64.28000

[ LogP ]:
0.95

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.533

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JG9650000

CHEMICAL NAME :: m-Dioxane, 5-bromo-5-nitro-

CAS REGISTRY NUMBER :: 30007-47-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C4-H6-Br-N-O4

MOLECULAR WEIGHT :: 212.02

WISWESSER LINE NOTATION :: T6O COTJ EE ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 455 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 31 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 590 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R38

[ Safety Phrases ]:
S36

[ RIDADR ]:
1759

[ WGK Germany ]:
3

[ RTECS ]:
JG9650000

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane (bronidox).

Folia Microbiol. (Praha) 31 , 19-31, (1986)

The mode of action of the antimicrobial agent, 5-bromo-5-nitro-1,3-dioxane (bronidox), was studied in detail for gram-positive and gram-negative bacteria, yeast and fungi. The studies included MIC tes...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.