Gamma-glutamylcysteine TFA

Names

[ CAS No. ]:
283159-88-6

[ Name ]:
Gamma-glutamylcysteine TFA

Biological Activity

[Description]:

Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Apoptosis >> TNF Receptor

[Target]

IL-10

IL-6

IL-1β

TNF-α


[References]

[1]. Braidy N, et al. The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ40 Oligomers in Human Astrocytes. Front Aging Neurosci. 2019 Aug 8;11:177.

Chemical & Physical Properties

[ Molecular Formula ]:
C10H15F3N2O7S

[ Molecular Weight ]:
364.30

[ Storage condition ]:
-20°C

Related Compounds