Trimethoprim N-oxide

Names

[ Name ]:
Trimethoprim N-oxide

[Synonym ]:
2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine 1-oxide
2,4-Pyrimidinediamine, 5-[(3,4,5-trimethoxyphenyl)methyl]-, 1-oxide

Biological Activity

[Description]:

Trimethoprim N-oxide (Trimethoprim 1-N-oxide) belongs to human urinary metabolites. Trimethoprim N-oxide is generated by oxidation of nitrogen atoms in the pyrimidine ring. Trimethoprim N-oxide is formed predominantly by CYP1A2 in human liver microsomes[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Goldman JL, et al. In Vitro Hepatic Oxidative Biotransformation of Trimethoprim. Drug Metab Dispos. 2015 Sep;43(9):1372-80.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₈N₄O₄

[ Molecular Weight ]:
306.31700

[ Exact Mass ]:
306.13300

[ PSA ]:
118.08000

[ LogP ]:
2.45350

Related Compounds

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