BRD4-BD1-IN-2

Names

[ Name ]:
BRD4-BD1-IN-2

Biological Activity

[Description]:

BRD4-BD1-IN-2 is a selective BRD4-BD1 inhibitor, with an IC50 of 2.51 µM (20-times greater than that of BD2). BRD4-BD1-IN-2 can be used in studies of cancer and cardiovascular diseases[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

BRD4-BD1:2.51 μM (IC50)

BRD4-BD2:＞50 μM (IC50)

[References]

[1]. Chang Y, et al. Design, synthesis, biological evaluation, and molecular docking of 1, 7-dibenzyl-substituted theophylline derivatives as novel BRD4-BD1-selective inhibitors. Medicinal Chemistry Research, 2021, 30(8): 1453-1468.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₅Br₃N₄O₂

[ Molecular Weight ]:
583.07

Related Compounds

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