HPK1-IN-28

Names

[ CAS No. ]:
2699603-89-7

[ Name ]:
HPK1-IN-28

Biological Activity

[Description]:

HPK1-IN-28 is a potent inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the activation response of dendritic cells (DCs), T cells and B cells. HPK1-IN-28 enhances the body's anti-tumor immunity. HPK1-IN-28 has the potential for the research of immune-related diseases, especially tumor (extracted from patent WO2021175270A1, compound 1)[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> MAP4K
Research Areas >> Cancer

[References]

[1]. Jiang Lei, et al. Novel hpk1 inhibitors and methods of preparation and application thereof. Patent WO2021175270A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H22F3N5O4

[ Molecular Weight ]:
513.47

Related Compounds