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JDQ-443

Names

[ CAS No. ]:
2653994-08-0

[ Name ]:
JDQ-443

Biological Activity

[Description]:

JDQ-443 (example 1a) is a covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRas G12C


[In Vitro]

JDQ-443 (NVP-JDQ443) traps the GDP-bound inactive conformation of KRAS[1].

[References]

[1]. LIU BO, et al. PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS. Patent WO2021120890A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H28ClN7O

[ Molecular Weight ]:
526.03

Related Compounds