Guaiacol acetate

Names

[ Name ]:
Guaiacol acetate

[Synonym ]:
EINECS 247-492-5
Guaiacol acetate
(2S)-Methoxy(phenyl)acetic acid
Phenol, o-methoxy-, acetate (8CI)
1-ACETOXY-2-METHOXYBENZENE
2-Methoxyphenyl acetate
Phenol, o-methoxy-, acetate
O-METHYL-L-MANDELIC ACID
Benzeneacetic acid, α-methoxy-, (αS)-
O-METHOXYPHENYL ACETATE
(S)-(+)-alpha-Methoxyphenylacetic Acid
MFCD00064216
Phenol, 2-methoxy-, acetate
o-Acetoxyanisole
Benzeneacetic acid, α-methoxy-, (S)-
(S)-(+)-α-Methoxyphenylacetic Acid
(2S)-methoxy(phenyl)ethanoic acid

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
283.8±0.0 °C at 760 mmHg

[ Melting Point ]:
64-66 °C(lit.)

[ Molecular Formula ]:
C₉H₁₀O₃

[ Molecular Weight ]:
166.174

[ Flash Point ]:
116.1±15.3 °C

[ Exact Mass ]:
166.062988

[ PSA ]:
46.53000

[ LogP ]:
1.29

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.535

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.

Bioorg. Med. Chem. 22(17) , 4968-97, (2014)

TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led t...