TM-25659

Names

[ CAS No. ]:
260553-97-7

[ Name ]:
TM-25659

Biological Activity

[Description]:

TM-25659 is a TAZ modulator. Anti-osteoporotic and anti-obesity activities[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[Target]

TAZ[1]

[In Vitro]

TM-25659 (2, 10, 20, 100 μM) enhances nuclear TAZ localization in a dose-dependent manner and attenuates PPARγ-mediated adipocyte differentiation by facilitating PPARγ suppression activity of TAZ[1].

[In Vivo]

Oral administration of TM-25659 has a favourable pharmacokinetic profile. TM-25659 (50 mg/kg) suppresses bone loss in vivo and decreases weight gain in an obesity model[1].

[References]

[1]. Jang EJ, et al. TM-25659 enhances osteogenic differentiation and suppresses adipogenic differentiation by modulating the transcriptional co-activator TAZ. Br J Pharmacol. 2012 Mar;165(5):1584-94.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₂₈N₈

[ Molecular Weight ]:
500.60

[ Storage condition ]:
2-8℃

Related Compounds

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