UC-764865
Names
[ CAS No. ]:
2566480-63-3
[ Name ]:
UC-764865
Biological Activity
[Description]:
UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764865 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.
[References]
1. Laura Barreyro, et al. Sci Transl Med. 2022 Mar 9;14(635):eabb7695.
Chemical & Physical Properties
[ Molecular Formula ]:
C18H16N2O2S
[ Molecular Weight ]:
324.398