1,6,7-Trihydroxy-9H-xanthen-9-one

Names

[ Name ]:
1,6,7-Trihydroxy-9H-xanthen-9-one

[Synonym ]:
9H-Xanthen-9-one, 1,6,7-trihydroxy-
1,6,7-Trihydroxy-xanthon
1,6,7-Trihydroxy-xanthen-9-on
1,6,7-trihydroxy-xanthen-9-one
W2665
1,6,7-Trihydroxy-9H-xanthen-9-one
1,6,7-Trihydroxyxanthone

Biological Activity

[Description]:

1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

1,6,7-Trihydroxyxanthone (0-10 µg/mL; 0-72 h) 抑制 HepG2、Bel7404 细胞的细胞增殖[1]。 1,6,7-Trihydroxyxanthone (5 µg/mL; 72 h) 诱导 HepG2 细胞凋亡[1]. 1,6,7-Trihydroxyxanthone 降低 Bmi-1 表达并增加 P14、P16 的蛋白表达水平[1]。 1,6,7-Trihydroxyxanthone 在 HepG2、Bel7404 细胞中诱导 MiR-218 上调[1]。 Cell Proliferation Assay[1] Cell Line: HepG2, Bel7404 cells Concentration: 0, 1.25, 2.5, 5, 10 µg/mL Incubation Time: 0, 24, 48, 72 h Result: Inhibited cell proliferation of HepG2 and Bel7404 in a time- and dose-dependent manner. Apoptosis Analysis[1] Cell Line: HepG2 cells Concentration: 5 μg/ml Incubation Time: 72 h Result: Induced cell apoptosis. Western Blot Analysis[1] Cell Line: HepG2, Bel7404 cells Concentration: Incubation Time: Result: Suppressed Bmi-1 expressio and increased the expression of P14, P16 protein levels.

[References]

[1]. Fu WM, et al. MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells. Apoptosis. 2015 Jan;20(1):75-82.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
509.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₈O₅

[ Molecular Weight ]:
244.20

[ Flash Point ]:
204.8±23.6 °C

[ Exact Mass ]:
244.037170

[ PSA ]:
90.90000

[ LogP ]:
1.50

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.758

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2932999099

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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