Fmoc-His(3-Me)-OH

Names

[ CAS No. ]:
252049-16-4

[ Name ]:
Fmoc-His(3-Me)-OH

[Synonym ]:
FMOC-HISTIDINE(3-ME)-OH
N-(9-FLUORENYLMETHOXYCARBONYL)-N-IMIDAZOLE-3-METHYL-L-HISTIDINE
Fmoc-His(p-Me)-OH
FMOC-N-P-METHYL-L-HISTIDINE

Biological Activity

[Description]:

Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC50s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca2+]i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel[1][2][3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Tanaka M, et al. His-Arg-Trp potently attenuates contracted tension of thoracic aorta of Sprague-Dawley rats through the suppression of extracellular Ca2+ influx. Peptides. 2009 Aug;30(8):1502-7.

[2]. Kumrungsee T, et al. Identification of peptides from soybean protein, glycinin, possessing suppression of intracellular Ca2+ concentration in vascular smooth muscle cells. Food Chem. 2014;152:218-24.

[3]. Arispe N, et al. Efficiency of histidine-associating compounds for blocking the alzheimer's Abeta channel activity and cytotoxicity. Biophys J. 2008 Nov 15;95(10):4879-89.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₁N₃O₄

[ Molecular Weight ]:
391.42000

[ Exact Mass ]:
391.15300

[ PSA ]:
93.45000

[ LogP ]:
3.34540

Related Compounds

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