Name | fmoc-his(3-me)-oh |
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Synonyms |
FMOC-HISTIDINE(3-ME)-OH
N-(9-FLUORENYLMETHOXYCARBONYL)-N-IMIDAZOLE-3-METHYL-L-HISTIDINE Fmoc-His(p-Me)-OH FMOC-N-P-METHYL-L-HISTIDINE |
Description | Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC50s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca2+]i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel[1][2][3]. |
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Related Catalog | |
References |
Molecular Formula | C22H21N3O4 |
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Molecular Weight | 391.42000 |
Exact Mass | 391.15300 |
PSA | 93.45000 |
LogP | 3.34540 |