uracil-d4

Names

[ CAS No. ]:
24897-55-0

[ Name ]:
uracil-d4

[Synonym ]:
tetradeuterio-propadiene
1,3,5,6-tetradeuterio-1H-pyrimidine-2,4-dione
Tetradeuterio-allen
tetradeuterio-allene
Tetradeuterouracil
perdeuterioallene
Perdeutero-uracil
Propadiene-d4
1,3,4,5-D4-Uracil

Biological Activity

[Description]:

Uracil-d4 is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Pałasz A, et al. In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications. Eur J Med Chem. 2015 Jun 5;97:582-611.  

Chemical & Physical Properties

[ Molecular Formula ]:
C4D4N2O2

[ Molecular Weight ]:
116.11100

[ Exact Mass ]:
116.05200

[ PSA ]:
65.72000

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds