AChE/BChE-IN-8

Names

[ CAS No. ]:
2421120-96-7

[ Name ]:
AChE/BChE-IN-8

Biological Activity

[Description]:

AChE/BChE-IN-8 (Compound 5a) is an uncompetitive AChE and mixed BChE inhibitor with Ki values of 0.788 μM and 2.364 μM against Electrophorus electricus AChE (EeAChE) and equine BChE (eqBChE), respectively. AChE/BChE-IN-8 can cross the BBB and has low cytotoxicity[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

Ki: 0.788 μM (EeAChE), 2.364 μM (eqBChE)[1]


[References]

[1]. Bortolami M, et al. New deferiprone derivatives as multi-functional cholinesterase inhibitors: design, synthesis and in vitro evaluation. Eur J Med Chem. 2020 Jul 15;198:112350.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H32N2O2

[ Molecular Weight ]:
404.54

Related Compounds