SIBIRICINE

Names

[ Name ]:
SIBIRICINE

[Synonym ]:
(8'R)-8'-Hydroxy-6-methyl-7,8-dihydro-6H-spiro[1,3-dioxolo[4,5-g]isoquinoline-5,7'-indeno[4,5-d][1,3]dioxol]-6'(8'H)-one
Spiro[1,3-dioxolo[4,5-g]isoquinoline-5(6H),7'-[7H]indeno[4,5-d][1,3]dioxol]-6'(8'H)-one, 7,8-dihydro-8'-hydroxy-6-methyl-, (8'R)-

Biological Activity

[Description]:

Sibiricine (Compound 8) is an isoquinoline alkaloid derived from the medicinal plant Corydalis crispa. Sibiricine has significant anti-inflammatory activity on TNF-α production by LPS-activated THP-1 cells[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Wangchuk P, et al. Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa. Nat Prod Commun. 2012 May;7(5):575-80.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
547.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₇NO₆

[ Molecular Weight ]:
367.352

[ Flash Point ]:
284.8±30.1 °C

[ Exact Mass ]:
367.105591

[ LogP ]:
3.28

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.743

Related Compounds

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