NOD2 antagonist 1

Names

[ CAS No. ]:
2411441-54-6

[ Name ]:
NOD2 antagonist 1

Biological Activity

[Description]:

NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)
Research Areas >> Inflammation/Immunology

[Target]

NOD2:5.23 μM (IC50)


[References]

[1]. Guzelj S, et al. Structural features and functional activities of benzimidazoles as NOD2 antagonists. Eur J Med Chem. 2020;190:112089.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H26N4O3S

[ Molecular Weight ]:
474.57

Related Compounds