DPP-4/GPR119 modulator 1

Names

[ CAS No. ]:
2411099-68-6

[ Name ]:
DPP-4/GPR119 modulator 1

Biological Activity

[Description]:

DPP-4/GPR119 modulator 1 (Compound 22) is an orally active dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist. DPP-4/GPR119 modulator 1 shows blood glucose-lowering effect and moderate inhibition on hERG channel with an IC50 of 4.9 µM. DPP-4/GPR119 modulator 1 can be used for diabetes research[1][1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase
Signaling Pathways >> GPCR/G Protein >> GPR119
Research Areas >> Metabolic Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 4.9 µM (hERG)[1]


[References]

[1]. Li G, et al. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur J Med Chem. 2020 Feb 15;188:112017.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H39ClN10O3

[ Molecular Weight ]:
623.15

Related Compounds