DPP-4 inhibitor 3

Names

[ CAS No. ]:
2402735-14-0

[ Name ]:
DPP-4 inhibitor 3

Biological Activity

[Description]:

DPP-4 inhibitor 3 (Compound 5a) is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 0.75 nM. DPP-4 inhibitor 3 shows excellent antioxidant and insulinotropic activity[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS
Research Areas >> Metabolic Disease

[Target]

IC50: 0.75 nM (DPP-IV)[1]


[References]

[1]. Bindu B, et al. Synthesis and discovery of triazolo-pyridazine-6-yl-substituted piperazines as effective anti-diabetic drugs; evaluated over dipeptidyl peptidase-4 inhibition mechanism and insulinotropic activities. Eur J Med Chem. 2020 Feb 1;187:111912.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H22N6O2

[ Molecular Weight ]:
366.42

Related Compounds