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IL-4-inhibitor-1

Names

[ CAS No. ]:
1332184-63-0

[ Name ]:
IL-4-inhibitor-1

[Synonym ]:
3-Pyridinecarbonitrile, 2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)-
IL-4 Inhibitor
2-Amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)nicotinonitrile

Biological Activity

[Description]:

IL-4-inhibitor-1 (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 µM[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

[Target]

EC50: 1.81 µM (IL-4)[1].


[In Vitro]

IL-4-inhibitor-1 (compound 52) displays low micromolar affinity and exhibits functional disruption of type II IL-4 binding in a cellular context[1]. IL-4-inhibitor-1 (compound 52) exhibits dose-dependent reduction in pSTAT-6 levels with an EC50 value of 3.1 µM, but did not affect the levels of STAT-6[1].

[References]

[1]. Sean P Quinnell, et al. A Small-Molecule Inhibitor to the Cytokine Interleukin-4. ACS Chem Biol. 2020 Oct 16;15(10):2649-2654.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
590.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H12FN3O2

[ Molecular Weight ]:
321.31

[ Flash Point ]:
311.0±30.1 °C

[ Exact Mass ]:
321.091370

[ LogP ]:
3.17

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.729

Related Compounds