MMP-8 INHIBITOR I

Names

[ Name ]:
MMP-8 INHIBITOR I

[Synonym ]:
(3R)-N-Hydroxy-2-[(4-methoxyphenyl)sulfonyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide
3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-, (3R)-

Biological Activity

[Description]:

MMP-8 inhibitor-1 (compound 21), a hydroxamic acid derivative, is a potent MMP-8 inhibitor without significant oral bioavailability[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

MMP-8

[References]

[1]. Matter H, et al. Tetrahydroisoquinoline-3-carboxylate based matrix-metalloproteinase inhibitors: design, synthesis and structure-activity relationship. Bioorg Med Chem. 2002 Nov;10(11):3529-44.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₇H₁₈N₂O₅S

[ Molecular Weight ]:
362.40

[ Exact Mass ]:
362.093628

[ LogP ]:
2.05

[ Index of Refraction ]:
1.629

Related Compounds

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