<Suppliers Price>

EIDD-2801

Names

[ CAS No. ]:
2349386-89-4

[ Name ]:
EIDD-2801

[Synonym ]:
Molnupiravir

Biological Activity

[Description]:

EIDD-2801 is an orally bioavailable isopropylester prodrug of the ribonucleoside analog EIDD-1931. EIDD-2801 shows anti-influenza virus and coronaviruses activities. EIDD-2801 has the potential for seasonal and pandemic influenza treatment[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[In Vivo]

EIDD-2801 (7 mg/kg; oral; twice daily for 3.5 days) significantly reduces shed virus load and duration of fever[1]. Animal Model: Ca/09-infected female ferrets[1] Dosage: 7 mg/kg Administration: Oral; twice daily for 3.5 days Result: Shed virus load and duration of fever were significantly reduced.

[References]

[1]. Toots M, et al. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci Transl Med. 2019 Oct 23;11(515). pii: eaax5866.

[2]. Timothy P. Sheahan, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H19N3O7

[ Molecular Weight ]:
329.31

[ Storage condition ]:
2-8℃

Related Compounds