2349386-89-4

2349386-89-4 structure

Name: EIDD-2801
Chemical Name: EIDD-2801
CAS Number: 2349386-89-4
Molecular Formula: C₁₃H₁₉N₃O₇
Molecular Weight: 329.31
Catalog: Signaling Pathways Anti-infection Influenza Virus
Create Date: 2020-04-07 22:45:02
Modify Date: 2024-01-16 17:08:45
EIDD-2801 is an orally bioavailable isopropylester prodrug of the ribonucleoside analog EIDD-1931. EIDD-2801 shows anti-influenza virus and coronaviruses activities. EIDD-2801 has the potential for seasonal and pandemic influenza treatment[1][2].

Name	EIDD-2801
Synonyms	Molnupiravir

Description	EIDD-2801 is an orally bioavailable isopropylester prodrug of the ribonucleoside analog EIDD-1931. EIDD-2801 shows anti-influenza virus and coronaviruses activities. EIDD-2801 has the potential for seasonal and pandemic influenza treatment[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
In Vivo	EIDD-2801 (7 mg/kg; oral; twice daily for 3.5 days) significantly reduces shed virus load and duration of fever[1]. Animal Model: Ca/09-infected female ferrets[1] Dosage: 7 mg/kg Administration: Oral; twice daily for 3.5 days Result: Shed virus load and duration of fever were significantly reduced.
References	[1]. Toots M, et al. Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci Transl Med. 2019 Oct 23;11(515). pii: eaax5866. [2]. Timothy P. Sheahan, et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus.