Lawsone methyl ether
Names
[ CAS No. ]:
2348-82-5
[ Name ]:
Lawsone methyl ether
[Synonym ]:
2-Methoxy-p-naphthoquinone
1,4-Naphthalenedione,2-methoxy
2-methoxy-1,4-naphthalenequinone
2-methoxynaphthalene-1,4-dione
2-Methoxy-[1,4]naphthoquinone
2-methoxyl-1,4-naphthoquinone
2-Methoxynaphthoquinone
1,4-NAPHTHOQUINONE,2-METHOXY
MFCD00019539
2-Methoxy-1,4-naphthalenedione
Methoxy-1,4-naphthochinin
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[References]
Chemical & Physical Properties
[ Density]:
1.28g/cm3
[ Boiling Point ]:
339.8ºC at 760mmHg
[ Melting Point ]:
184-187ºC(lit.)
[ Molecular Formula ]:
C11H8O3
[ Molecular Weight ]:
188.17900
[ Flash Point ]:
152.7ºC
[ Exact Mass ]:
188.04700
[ PSA ]:
43.37000
[ LogP ]:
1.59590
[ Vapour Pressure ]:
8.98E-05mmHg at 25°C
[ Index of Refraction ]:
1.589
[ Storage condition ]:
-20℃
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QL8960000
- CHEMICAL NAME :
- 1,4-Naphthoquinone, 2-methoxy-
- CAS REGISTRY NUMBER :
- 2348-82-5
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C11-H8-O3
- MOLECULAR WEIGHT :
- 188.19
- WISWESSER LINE NOTATION :
- L66 BV EVJ CO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,570,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 316 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
36/37/38
[ Safety Phrases ]:
S26;S36
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
QL8960000
[ HS Code ]:
2914690090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914690090
[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
Life Sci. 135 , 158-64, (2015)
The compound 2-methoxy-1,4-naphthoquinone (MNQ) was previously shown to be cytotoxic against several cancer cell lines, but its mode of action is poorly understood. In this study, we aimed to explore ...
Anti-gastric adenocarcinoma activity of 2-Methoxy-1,4-naphthoquinone, an anti-Helicobacter pylori compound from Impatiens balsamina L.Fitoterapia 83(8) , 1336-44, (2012)
2-Methoxy-1,4-naphthoquinone (MeONQ) from Impatiens balsamina L. exhibited strong anti-H. pylori activity in our previous study. In this study, we investigated the cytotoxicity of MeONQ against gastri...
Effects of the compounds 2-methoxynaphthoquinone, 2-propoxynaphthoquinone, and 2-isopropoxynaphthoquinone on ecdysone 20-monooxygenase activity.Arch. Insect Biochem. Physiol. 66(1) , 45-52, (2007)
The effects of the natural compound 2-methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera and the synthetic compounds 2-propoxy-1,4-naphthoquinone and 2-isopropoxy-1,4-napht...