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Geissoschizine methyl ether

Names

[ CAS No. ]:
60314-89-8

[ Name ]:
Geissoschizine methyl ether

[Synonym ]:
Indolo[2,3-a]quinolizine-2-acetic acid, 3-ethylidene-1,2,3,4,6,7,12,12b-octahydro-α-(methoxymethylene)-, methyl ester, (αZ,2S,3E,12bS)-
Methyl (16Z,19E)-16-(methoxymethylene)coryn-19-en-17-oate
methyl (Z)-2-[(2S,3E,12bS)-3-ethylidene-2,4,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate

Biological Activity

[Description]:

Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is potent 5-HT1A receptor agonist[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT1A[2]


[References]

[1]. Matsumoto T, et al. In vitro identification of human cytochrome P450 isoforms involved in the metabolism of Geissoschizine methyl ether, an active component of the traditional Japanese medicine Yokukansan. Xenobiotica. 2016;46(4):325-34.

[2]. Nishi A, et al. Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin ₁A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan. Neuroscience. 2012 Apr 5;207:124-36.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3, 计算值

[ Molecular Formula ]:
C22H26N2O3

[ Molecular Weight ]:
366.45300

[ Exact Mass ]:
366.19400

[ PSA ]:
54.56000

[ LogP ]:
3.67450

Related Compounds