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BRM/BRG1 ATP Inhibitor-1

Names

[ CAS No. ]:
2270879-17-7

[ Name ]:
BRM/BRG1 ATP Inhibitor-1

Biological Activity

[Description]:

BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: ﹤0.005 µM (BRM, BRG1)[1]


[References]

[1]. Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172

Chemical & Physical Properties

[ Molecular Formula ]:
C11H9F3N4O2S

[ Molecular Weight ]:
318.27

[ Storage condition ]:
-20°C

Related Compounds