Rafoxanide

Names

[ Name ]:
Rafoxanide

[Synonym ]:
N-[3-Chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide
EINECS 245-148-9
N-[3-Chlor-4-(4-chlorphenoxy)phenyl]-2-hydroxy-3,5-diiodbenzolcarboxamid
MFCD00682899
Rafoxanide
3'-Chloro-4'-(4-chlorophenoxy)-3,5-diiodosalicylanilide
3’-chloro-4’-(4-chlorophenoxy)-3,5-diiodosalicylanilide
Benzamide, N-(3-chloro-4-(4-chlorophenoxy)phenyl)-2-hydroxy-3,5-diiodo-
Benzamide, N-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodo-
3'-Chlor-4'-<4-chlor-phenoxy>-3,5-dijod-salicyl-anilid

Biological Activity

[Description]:

Rafoxanide is a salicylanilide used as an antiparasitic agent.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
526.6±50.0 °C at 760 mmHg

[ Melting Point ]:
169ºC

[ Molecular Formula ]:
C₁₉H₁₁Cl₂I₂NO₃

[ Molecular Weight ]:
626.010

[ Flash Point ]:
272.3±30.1 °C

[ Exact Mass ]:
624.820496

[ PSA ]:
58.56000

[ LogP ]:
9.36

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.753

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VN7870000

CHEMICAL NAME :: Salicylanilide, 3'-chloro-4'-(p-chlorophenoxy)-3,5-diiodo-

CAS REGISTRY NUMBER :: 22662-39-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H11-Cl2-I2-N-O3

MOLECULAR WEIGHT :: 626.01

WISWESSER LINE NOTATION :: QR BI DI FVMR CG DOR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cattle

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: REMVAY Revue d'Elevage et de Medicine Veterinaire des Pays Tropicaux. (Editions Vigot, 23 rue de l'Ecole-de-Medecine, F-75006 Paris, France) V.1- 1947- Volume(issue)/page/year: 29,31,1976

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
VN7870000

[ HS Code ]:
2924299090

Preparation

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

The Hymenolepis diminuta-golden hamster (Mesocricetus auratus) model for the evaluation of gastrointestinal anticestode activity.

J. Parasitol. 90(4) , 898-9, (2004)

A novel laboratory anticestode assay was developed using Hymenolepis diminuta in the hamster. The commercial anticestode compounds, praziquantel, bunamidine, and niclosamide were active against patent...

An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide.

Toxicol. Lett. 208(1) , 30-5, (2012)

A number of environmental chemicals have been reported to exhibit thyroid hormone-like activity. Since thyroid hormones play a crucial role in development, it is important to identify chemicals in the...

Screening of closantel and rafoxanide in animal muscles by HPLC with fluorescence detection and confirmation using MS.

J. Sep. Sci. 33(2) , 206-11, (2010)

A sensitive and selective LC-FLD method was described for determination of closantel and rafoxanide in bovine and ovine muscles. Bovine and ovine muscles were extracted with ACN and acetone mixture (8...