TH-Z145

Names

[ CAS No. ]:
2260887-57-6

[ Name ]:
TH-Z145

Biological Activity

[Description]:

TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 210 nM)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

FPPS[1]


[In Vivo]

TH-Z145 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model[1]. Animal Model: B16-OVA cells (s.c.) xenograft mice model[1]. Dosage: 20 μg Administration: Intraperitoneal injection (i.p.) Result: Inhibited tumor growth and prolonged survival.

[References]

[1]. Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H28O7P2

[ Molecular Weight ]:
394.34

Related Compounds