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TH-Z93

Names

[ CAS No. ]:
2260887-09-8

[ Name ]:
TH-Z93

Biological Activity

[Description]:

TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 90 nM)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

FPPS[1]


[In Vivo]

TH-Z93 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model[1]. Animal Model: B16-OVA cells (s.c.) xenograft mice model[1]. Dosage: 20 μg Administration: Intraperitoneal injection (i.p.) Result: Intraperitoneal injection (i.p.)

[References]

[1]. Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H22N2O7P2

[ Molecular Weight ]:
368.26

Related Compounds