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RAS GTPase inhibitor 1

Names

[ CAS No. ]:
2252242-32-1

[ Name ]:
RAS GTPase inhibitor 1

Biological Activity

[Description]:

RAS GTPase inhibitor 1 (example 51) is a RAS GTPase inhibitor with anti-tumor activity, extracted from patent WO2018212774A1. RAS GTPase inhibitor 1 (example 51) exhibits an EC50 less than 1 μM for at least one nucleotide exchange and an IC50 less than 1 μM in H727 cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

IC50: < 1 μM (H727 cells)[1]. EC50: < 1 μM (nucleotide exchange)[1].


[References]

[1]. WATERSON, Alex G, et al. QUINAZOLINE COMPOUNDS AS MODULATORS OF RAS SIGNALING. Patent. WO2018212774A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H28ClF4N5O2

[ Molecular Weight ]:
565.99

Related Compounds