BAY 6035

Names

[ Name ]:
BAY 6035

Biological Activity

[Description]:

BAY-6035 is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC50 of 88 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[Target]

SMYD3:88 nM (IC50)

[In Vitro]

BAY-6035 inhibits in vitro methylation of MEKK2 peptide with an IC50 of 88 nM and has more than 100-fold selectivity over other histone methyltransferases[1]. BAY-6035 inhibits the methylation of MEKK2 in cells with an IC50 of 70 nM[1].

[References]

[1]. Edoardo F, et, al. Small-molecule inhibitors of lysine methyltransferases SMYD2 and SMYD3: current trends. Future Med Chem. 2019 Apr; 11(8): 901-921.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₈N₄O₃

[ Molecular Weight ]:
396.48

BAY 6035

Names

Biological Activity

Chemical & Physical Properties

Related Compounds